When referring to Infinium-based DNA methylation datasets that are publicly available on TCGA, CpG sites located in the 5’ promoter regions of the genes (FAM123A, GLI3, PPP1R16B, SLIT3, and TMEM90B) harbor a high level of methylation in CRCs but low levels of methylation in most other tissue types of cancer (Supplementary Figure S4). The gene discussed is GLI3; the disease is cancer.