IGF2 and colorectal carcinoma: In addition, miR-486-5p was found to promote the proliferation and migration of CRC by activating the pleiomorphic adenoma gene-like 2 (PLAGL2), Insulin-like growth factor 2 (IGF2) andβ-catenin signaling pathway in vivo and in vitro, which is a promising therapeutic target for the treatment of patients with CRC [26].