The deficiency of ACE2 also resulted in the inflammatory response in the myocardial infarction regions, triggering neutrophilic infiltration, increasing of interferon γ (IFNγ), and interleukin-6 (IL-6), and activating the downstream extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase 1/2 (JNK1/2) pathways [60]. Here, MAPK3 is linked to myocardial infarction.