Multiple genes could be affected during the carcinogenesis of HCC, including the telomerase reverse transcriptase (TERT) promoter, beta-1 catenin (CTNNB1), TP53, axis inhibitor-1 (AXIN1), AT-rich interaction domain-containing protein 1A (ARID1A), nuclear factor erythroid 2-like 2 (NFE2L2), ARID2, tuberous sclerosis 1 (TSC1), TSC2, and ribosomal protein S6 kinase 90-kD 3 (RPS6KA3) [64]. The gene discussed is AXIN1; the disease is hepatocellular carcinoma.