Age, disease duration, treatment duration, DAS28, CRP, ESR, CCP, RF, synovitis score on GSUS, synovitis score on PDUS, tenosynovitis score on GSUS, tenosynovitis score on PDUS, 7-joint ultrasonic bone erosion, and total US7 scores were designated as variables X1-X14, respectively. The gene discussed is ESR1; the disease is synovitis.