Current treatment strategies for hypertension aim to limit the influence of the sympathetic nervous system and renin-angiotensin-aldosterone system on blood pressure, either directly with agents such as adrenoreceptor antagonists (beta blocker, alpha blocker), angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor antagonists or indirectly using diuretics or vasodilators like calcium channel blockers. The gene discussed is REN; the disease is hypertensive disorder.