AGT and endothelial dysfunction: γδ T cells serve as a “first line of defense” or “bridge between innate and adaptive responses.” Genetic knockout of γδ T cells or antibody-induced γδ T cell depletion blunt Ang II-induced blood pressure increases, and endothelial dysfunction suggesting these cells may play a causal role in blood pressure elevation (Caillon et al. 2017; Li et al. 2014).