Anti-CD20 therapy protected against Ang II-dependent hypertension as did genetic deficiency of either the B cell activating factor receptor (Tnfrsf13c−/− mice) or the transcription factor Myb (c- mybh/h mice), which renders mice devoid of mature B cells (Chan et al. 2015; Dingwell et al. 2019; Drummond et al. 2019). This evidence concerns the gene AGT and hypertensive disorder.