The first conclusive evidence for a role of T cells in the pathogenesis of arterial hypertension was provided by Guzik et al. in 2007 by showing that the increase in blood pressure caused by Ang II infusion was significantly blunted in mice lacking the recombinase-activating gene 1 (RAG-1−/− mice), a strain that lacks T and B cells (Guzik et al. 2007). This evidence concerns the gene AGT and Hypertension.