Specifically, osteoblast lineage‐specific SIRT6 KO mice established using the osteocalcin promoter exhibited osteopenia, which was attributed to a paracrine activation of osteoclastogenesis due to decreased osteoprotegerin (OPG) levels without changes in osteoblast function (Kim et al., 2020). The gene discussed is SIRT6; the disease is Osteopenia.