IL7R mediates the signaling of IL7, affecting the role of IL7 in regulating the development of T and B cells and the balance of the internal environment of T cells [44], and IL7R is involved in the pathogenesis of several autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus etc. [45] High altitude also could cause changes in different immune cells [46]. Here, IL7 is linked to rheumatoid arthritis.