In our study, the molecular mechanism of the effect of omeprazole on GC cells through regulating FTO / mTORC1 signal axis includes two aspects: first, FTO inhibition induced by omeprazole enhanced the activation of mTORC1 signal pathway that inhibited the prosurvival autophagy so as to improve the cell apoptosis on GC cells induced by chemotherapeutic drugs. The gene discussed is FTO; the disease is gastric cancer.