We first investigated the proportion of Dclk1+ cells in PanINs and PDACs established in Pdx1-Flp; KrasFSF-G12D/+ (KF) and Pdx1-Flp; KrasFSF-G12D/+; Trp53frt/frt (KPF) mice, well-established mouse models of pancreatic tumors (Schönhuber et al., 2014). Here, PDX1 is linked to pancreatic neoplasm.