GPX3 and melanoma: GPX3 has been reported to be downregulated in several types of cancers such as GPX3 downregulation that can promote the proliferation, motility, and invasion of melanoma cells in vitro.15Qi et al found that GPX3 low expression was significantly associated with advanced tumor stage, venous infiltration, and poor overall survival in HCC patients10as well as in gallbladder cancer16that has been shown poor prognosis.