Even in glioma, one study has demonstrated the frequent loss of PLAGL1 in their clinical samples.36 On the other hand, another study paradoxically demonstrated a pro-tumorigenic function of PLAGL1 driven by SOX11.37 Here, using the preclinical models, we provide a set of experimental evidence to support the tumorigenic function of PLAGL1 in glioblastoma TICs. The gene discussed is PLAGL1; the disease is central nervous system cancer.