To this end, we used our recently published RNA-seq data with 2 well-characterized tumor core-derived glioma sphere models; g267 for shRNA and g1005 for flow cytometry.19 As a result, PLAGL1 was identified as being the gene whose expression most strongly correlated with that of CD109 (FC>1.5, P < .05; Figure 2A and D, Supplementary Figure 3A and B). Here, CD109 is linked to glioma.