The protein encoded by mitogen-activated protein kinase 9 (MAPK9), also known as c-Jun N-terminal kinase 2 (JNK2), is involved in regulating various cellular processes, including cell growth, transformation, and apoptosis.28 This pathway can also be activated by growth factors, such as epidermal growth factor and platelet-derived growth factor.29–31 Targeted inhibition of MAPK9 with specific antisense oligonucleotides resulted in marked growth suppression in human GBM T98 cells, suggesting that MAPK9 inhibition could have therapeutic benefit.32 Here, MAP3K9 is linked to glioblastoma.