For the remaining 8 genes (HRH1, TYK2, RRM2, MAPK9, PDK3, XIAP, NR3C1, and NCOA1), an additional literature search in Pubmed and http://www.genecards.org/ was performed, which identified RRM2, MAPK9, and XIAP as members of biological pathways that play an important role in the development of GBM (Figure 1). Here, TYK2 is linked to glioblastoma.