Nevertheless, this study suggests that decreasing global IGF‐1 bioavailability is overall beneficial for slowing down age‐associated IDD, but more temporal and spatial studies aimed at upregulating and downregulating IGF‐1 signaling are needed to further elucidate the mechanisms by which it impacts disc matrix homeostasis and age‐associated IDD. This evidence concerns the gene IGF1 and intervertebral disk degenerative disorder.