Since pre-treatment of Raji cells with naringenin, a kind of favanon, enhanced NK cell lysis activity by induction of NKG2D ligands, targets of NK cell activation receptor NKG2D [29], treatment of NK cells with cirsiliol and treatment of cancer cells with naringenin may simultaneously potentiate the anti-cancer activity of NK cells to cancer cells. This evidence concerns the gene KLRK1 and cancer.