Down regulation of STAT3 targets, such as survivin, Cyclin-D1, -D2 and -D3 by carnosol in human colon cancer HCT116 cells and down regulation of survivin, myeloid cell leukemia sequence-1 (Mcl-1) and B-cell lymphoma-extra large (Bcl-xL) by luteolin in human gastric cancer cells, such as HGC27 cells has also been reported [4,5]. This evidence concerns the gene BIRC5 and colonic neoplasm.