MiR-199a targets the glycogen synthase kinase 3β (GSK3β)/mammalian target of rapamycin (mTOR) complex signaling pathway to impair cardiomyocyte autophagy and thereby enhancing cardiac hypertrophy (miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation). This evidence concerns the gene MTOR and cardiac hypertrophy.