TLR8 and familial dilated cardiomyopathy: Interestingly, the differentially expressed mRNAs that we identified, including CACNA2D2, IGF1, PRKCA, PIK3CA, VAV3, PRKCQ, TLR4, IL1B, TLR8, and CTNNBIP1, are involved in pathways relevant to DCM pathogenesis such as “dilated cardiomyopathy,” “leukocyte transendothelial migration,” “T cell receptor signaling pathways,” “Toll-like receptor signaling pathways,” and “WNT signaling pathways.”