Specifically, overexpression of PCOLCE mRNA was linked to worse OS and PFS in stage II to IV of gastric cancer patients (P<0.05) but has little influence on OS or PFS of patients in stage I (OS HR = 1.52, 95% CI = 0.55–4.22, P = 0.42; PFS HR = 0.47, 95% CI = 0.15–1.52, P = 0.20). The gene discussed is PCOLCE; the disease is gastric cancer.