Theacrine upregualted the expression of sirtuin family member SIRT3, which in turn activated the SIRT3/FOXO3/SOD2 signaling pathway, resulting in improvement of the intervertebral disc degeneration (19) and the cardiac function of ovariectomized mice with myocardial infarction (20) by alleviating oxidant stress. Here, SIRT3 is linked to Intervertebral disk degeneration.