Tests using multiple animal models of PD (6-OHDA-treated rats and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice and zebrafish) and 1-methyl-4-phenylpyridinium (MPP+)-treated SH-SY5Y cells showed that theacrine had the potency to relieve PD by retrieving the apoptosis of dopaminergic neurons and activating SIRT3 which deacetylating SOD2 and restoring mitochondrial functions (46). This evidence concerns the gene SIRT3 and Parkinson disease.