Consistent with our OXPHOS and ATP levels, we found that mitochondrial encoded gene DNA levels were decreased [Mt_Nd1 (1 vs. 0.84-fold) and Mt_Nd6 (1 vs. 0.87-fold)] in rats anesthetized with isoflurane and exposed to sepsis, but slightly increased in those anesthetized with Propofol and exposed to sepsis (Figure 6). The gene discussed is MT-ND1; the disease is Sepsis.