At a log2FC>2 (adjusted P < 0.05) (Figure 8A) MAPK related genes F2rl1, Adm (marked as multi, as it was picked up for term searches “metabolic,” “hypoxia,” and “MAPK”), Mapk4, Gdf15, Dusp10, and Dusp8 were up-regulated in Isoflurane-Sepsis compared to only 2 genes (Figure 8B) in the Propofol-Sepsis group. This evidence concerns the gene GDF15 and Sepsis.