PKD1 and autosomal dominant polycystic kidney disease: RNA expression profiling of ADPKD and Pkd1–/– kidney cysts compared with healthy kidney tissue supports the targeting of the RhoA-YAP-cMyc axis (Cai et al., 2018), but wider profiling could be useful to identify other pathways to target at specific timepoints in cystogenesis or for particular genotypes.