RNA expression profiling of ADPKD and Pkd1–/– kidney cysts compared with healthy kidney tissue supports the targeting of the RhoA-YAP-cMyc axis (Cai et al., 2018), but wider profiling could be useful to identify other pathways to target at specific timepoints in cystogenesis or for particular genotypes. This evidence concerns the gene RHOA and autosomal dominant polycystic kidney disease.