FLNA was first linked to centrosomal trafficking and initiation of ciliogenesis through the identification of a patient with both MKS and PH (Adams et al., 2012), who was found to have a mutation in TMEM67 (c.2754_2756delCTT, p.I918_F919del), deleting two residues in the C-terminal cytoplasmic region shown to directly interact with FLNA. The gene discussed is FLNA; the disease is Meckel syndrome, type 1.