Several growth factors, including basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), transforming growth factors (TGF), and insulin-like growth factors 1 and 2 (IGF-1 and IGF-2), have been reported to be significantly up-regulated in melanoma cells (Polsky and Cordon-Cardo, 2003; Menezes et al., 2018). This evidence concerns the gene IGF1 and melanoma.