ITGAM and systemic lupus erythematosus: CD11b serves as a signaling regulator and its deficiency has been implicated in the development of inflammatory diseases, such as systemic lupus erythematosus (SLE), lupus nephritis and rheumatoid arthritis (Ehirchiou et al., 2007; Reed et al., 2013; Stevanin et al., 2017; Khan et al., 2018).