ITGAM and systemic lupus erythematosus: It has also been revealed that CD11b is involved in MyD88/TRIF pathway in SLE, by decreasing IFN-α,β and NF-κB transcribed cytokines, namely interleukin-6 (IL-6) (Faridi et al., 2017), which can promote calcium-containing crystal formation (Nasi et al., 2016b).