Finally, recent findings have also highlighted a critical role of NEU1 in immune thrombocytopenia induced by anti-GPIbα autoantibodies by a mechanism involving Fc-independent platelet activation, NEU1 translocation to the plasma membrane, desialylation, and platelet clearance in the liver via hepatocyte Ashwell–Morell receptors (Li et al., 2015). This evidence concerns the gene NEU1 and autoimmune thrombocytopenic purpura.