IFN-induced proteins with tetratricopeptide repeats (IFITs) could be generated through the IFN-γ–JAK–STAT1/2 pathway to fight against pathogen infection, and IFIT1-deficiency mice are more sensitive to Burkholderia cenocepacia (Van Treuren and Dodd, 2020; Zheng et al., 2020). Here, STAT1 is linked to infection.