NGF and bone neoplasm: Given the impact of NGF in cancer pain, NGF blockade inhibits the sprouting of sensory nerve fibers and alleviates cancer-associated pain, especially bone cancer pain, through anti-hyperalgesia (i.e., normalizing a downregulated nociceptive threshold) (Bloom et al., 2011; Jimenez-Andrade et al., 2011; Mizumura and Murase, 2015).