SOD1 and amyotrophic lateral sclerosis: ALS exhibits multiple pathogenic features, including oxidative stress, mitochondrial dysfunction, and protein dysfunction of 43-kDa transactivating response region binding protein (TDP-43) and cytoplasmic Cu2+/Zn2+-superoxide dismutase 1 (SOD1) (Ferraiuolo et al., 2011; Lee et al., 2011; Tadic et al., 2014).