ALS patient fibroblast-derived motor neurons with C9ORF72 and TDP-43 mutations show delayed clearance of cytosolic Ca2+, lower mitochondrial buffering capacity, and imbalance of MICU1 and MICU2 expression (Dafinca et al., 2020) (Figure 1 and Table 1). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.