First, many previous studies on gliomas found that the decline in miR-7-5p expression in gliomas causes the activation of the PI3K/AKT pathway, resulting in increased tumor cell proliferation (Kefas et al., 2008; Liu et al., 2014; Shukla et al., 2018; Xiao, 2019; Yin et al., 2019). This evidence concerns the gene AKT1 and glioma.