TBX22 and neoplasm: In the TCGA cohort, the mRNA level of TBX22 in PTC patients was significantly associated with tumor size (Figure 2A, p = 1.6e-05), nodal metastasis (Figure 2B, p = 1.9e-06), extrathyroidal extension (Figure 2C, p = 7.1e-08), and disease stage (Figure 2D, p = 0.003).