As a member of the T-box gene family, T-box transcription factor 22 (TBX22) mutations caused a high risk of incidence in several diseases, including non-syndromic cleft palate, hypodontia, and ankyloglossia (Braybrook et al., 2001; Kantaputra et al., 2011). Here, TBX22 is linked to cleft palate.