Changes in Mfn2 expression in cardiac hypertrophy have been studied in several disease models—from spontaneously hypertensive rats to pressure-overload hypertrophy caused by transverse aortic constriction (TAC) (Fang et al., 2007; Givvimani et al., 2014; Hall et al., 2016). This evidence concerns the gene MFN2 and cardiac hypertrophy.