DNM1L and dilated cardiomyopathy: By combining Drp1 and cardiac myocyte-targeted Cre alleles in mice with cardiac Drp1 knockout, it was shown that the inhibition of fission ultimately resulted in a loss of cardiac myocyte mitochondria and lethal dilated cardiomyopathy (Dorn et al., 2015; Qin et al., 2020).