We established a risk score model based on the expressions of these six genes and corresponding coefficients for patients with ESCC: risk score = (0.1272 × TSPAN2 expression) + (0.2423 × AMBP expression) + (0.2201 × C6 expression) + (0.1651 × PRLR expression) − (0.2720 × ITLN1 expression) − (0.2724 × MADCAM1 expression). Here, TSPAN2 is linked to esophageal squamous cell carcinoma.