Similarly, in metastatic settings fewer oncologists compared with those before the emergency adopted weekly paclitaxel upfront for Her-2-positive disease (41.8 vs. 53.9%) or CDK 4/6 inhibitors for ER-positive HER2-negative metastatic breast cancers with less-aggressive features (55.8 vs. 80%) (16). This evidence concerns the gene ERBB2 and breast cancer.