Among many tested, the most utilized have been: CXCL12, CD40L, and IL-4, to prolong CLL cell survival (30); anti-IgM to increase BCR and NF-kB signaling and overall activation of the leukemic cells; CpG (with or without IL-2) to induce proliferation besides prolonging survival (31). This evidence concerns the gene CD40LG and B-cell chronic lymphocytic leukemia.