Almonertinib has been approved recently by National Medical Products Administration (NMPA) in China, exhibited a median PFS of 12.3 months, acceptable toxicity and an ORR of 68.9% in second-line treatment of EGFR-mutant NSCLC after drug resistance in the phase II APOLLO trial (17). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.