EGFR and non-small cell lung carcinoma: Then, the phase III trial FLAURA of osimertinib in previously untreated, EGFR mutation-positive (ex19del or L858R), advanced NSCLC compared to standard EGFR TKIs suggested its efficacy at delaying acquired resistance with a median progression free survival (PFS) of 18.9 months and overall survival (OS) of 38.6 months and less adverse events of grade 3 or higher in first-line therapy (22).