As a scaffold molecule, lncRNA CCAT1 was shown to bind two distinct epigenetic modification complexes [5’-domain of CCAT1 binds PRC2, while 3’-domain binds the suppressor of variegation 3-9 homolog 1 (SUV39H1)], thus regulating the histone methylation pattern of the sprouty RTK signaling antagonist 4 (SPRY4) promoter, and ultimately promoting the proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) (43). The gene discussed is SPRY4; the disease is esophageal squamous cell carcinoma.