Mice were administrated with anti-CXCR4 scFvs (aCX73 and aCX82, 10 mg/kg), the negative control antibody (Her2-13C1, 10 mg/kg) and DDP (2 mg/kg) as a positive control when the tumor volumes were about 100 mm3. The gene discussed is ERBB2; the disease is neoplasm.