Immunohistochemistry analysis of tumors showed a significantly decreased Ki67 and CD31 expression and a significantly increased c-caspase-3 expression in mice treated with the scFvs compared to the negative control antibody Her2-13C1 (Figures 10E, F), suggesting that the two scFvs significantly decreased cancer cell proliferation and tumor angiogenesis and increased cell apoptosis. The gene discussed is MKI67; the disease is cancer.