TLR4 and colitis: For example, miR-146b induced by IL-10-IL-10R signaling regulated the Toll-like receptor 4 (TLR4) by negative feedback in human monocytes (7), and miR-146b deficient mice easily develop colitis by targeting IRF5 (8), which was regarded as a regulator of TLRs in LPS-driven TLR signaling.