In the process of the CRC, IL-17 expression in miR-124 mimic treated mice was lower than that in the controlled group (Figures 5D, E), suggesting that chronic inflammation by AOM/DSS impaired the colonic epithelial microenvironment and the TH17 cells function, resulting in development of inflammation induced cancer, and TH17 cells were recruited around the neoplastic epithelial cells in regeneration, and the concomitant alteration was also exhibited in stat3 expression. Here, STAT3 is linked to infectious otitis media.