The importance of the risk factors in the ANN model for the BCLC stage, ALBI grade, maximum tumor size (≤5, 5–10, or >10 cm), CTP grade, intrahepatic tumor location (unilobe or multilobe), intrahepatic tumor number (single or multiple), and plasma alpha-fetoprotein (AFP) (≤200 ng/dl or >200 ng/dl) were 0.222, 0.187, 0.163, 0.144, 0.120, 0.111, and 0.055, respectively. The gene discussed is AFP; the disease is neoplasm.