By embolizing targeted arteries of the lesions to achieve tumor control, TACE induces ischemic and hypoxic changes that lead to an increase in vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) expression locally in the residual lesion(s), which theoretically promotes recurrence or progression (7–9). The gene discussed is VEGFA; the disease is neoplasm.