TNFRSF8 and neoplasm: Similarly, drastic tumor reductions were observed with the engagement of neutrophils with tumor cells in the presence of anti-EGFR, HER2, CD30, and Ep-CAM antibodies of IgA isotype 9, 12 possibly through the release of chemoattractant Leukotriene B4 (LTB4), which causes increased neutrophil accumulation in the tumor microenvironment 13.