However, other studies have indicated that COL6A1 can promote metastasis as knockdown of COL6A1 suppressed the metastatic ability of lung cancer and pancreatic cancer by regulating expression of proteins related to EMT 25.The present study indicated that increased expression of COL6A1 in OS cells significantly promoted cell adhesion, migration and invasion in vitro and in vivo. This evidence concerns the gene COL6A1 and familial pancreatic carcinoma.