The experiments revealed that STAT1 plays a tumor suppressor role in OS, which is consistent with previous reports that showed that the forced expression of STAT1 can repress tumor metastasis in variety of cancer types, such as fibrosarcoma, head and neck squamous cell carcinoma, gastric cancer, breast cancer, and lung adenocarcinoma 30. This evidence concerns the gene STAT1 and head and neck squamous cell carcinoma.