NFKB1 and oral cavity squamous cell carcinoma: It has been reported that the knockdown of AIM2 downregulates nuclear factor κB (NF-κB) expression, resulting in the suppression of cell growth and apoptosis in oral squamous cell carcinoma 26, while the transcription factor NF-κB binds to the BCL2A1 promoter induces its mRNA transcription 27.