SLC9A1 and myocardial infarction: A new selective NHE1 inhibitor, N-[4-(1-acetyl-piperidin-4-yl)-3-trifluoromethyl-benzoyl]-guanidine (BIX) has been identified with high selectivity against NHE1 (IC50, 6 nM) in comparison with cariporide (IC50, ~ 0.03-3.4 μM), and potentially lower effects on platelets 56 proved effective in the prevention of ischemic myocardium damages in a rat myocardial infarction model 57.