Owing to some common pathological mechanisms between aortic valve calcification and vascular calcification, such as activation of Wnt signaling pathway, alkaline phosphatase (ALP), BMP2 and RUNX2 40-42, the association between activated ERK1/2 and aortic valve calcification in human samples implies ERK1/2 inhibitor, such as U0126, can reduce vascular calcification. The gene discussed is RUNX2; the disease is aortic valve calcification.