Besides these effectors, Irie's group also reported that in DOV-13 ovarian cancer cells and in breast cancer cells, BRK appears to have a positive role in affecting IGF-1 induced anoikis, which is a form of programmed cell death for anchorage dependent cells when they detach from the extracellular matrix (ECM) 28. This evidence concerns the gene PTK6 and breast carcinoma.