In this study, we used multiple murine infection models with S. japonicum infection or SEA and Sjp40 injection to report, for the first time, that schistosome infection or schistosome-derived molecules can downregulate host miRNA-802 expression, which interacts with mouse Prkab1 or human Prkaa1, resulting in activation of the AMPK pathway and subsequent suppression of hepatic lipogenesis. This evidence concerns the gene PRKAA1 and infection.