It has been reported that increased expression of miR-802 is a possible biomarker of type 2 diabetes and disordered glucose metabolism in obese people and mice 32, 33, our study further provide evidence that abnormally expression of miR-802 in obesity plays a causative role in lipid metabolic dysregulation, at least in part, by targeting the hepatic AMPK signaling. Here, PRKAA2 is linked to obesity due to melanocortin 4 receptor deficiency.