In this study, we used multiple murine infection models with S. japonicum infection or SEA and Sjp40 injection to report, for the first time, that schistosome infection or schistosome-derived molecules can downregulate host miRNA-802 expression, which interacts with mouse Prkab1 or human Prkaa1, resulting in activation of the AMPK pathway and subsequent suppression of hepatic lipogenesis. Here, PRKAA2 is linked to infection.