While our current study showed that the SNI-induced pathological changes, including increase in circulating leukocytes (Figures 1A, B and S3A, B), brain PVMs (Figures 2, S3C, and S4), and gliosis (Figures 4 and S4D, E), the elevation of plasma CXCL12 (Figure 6A-D) and SNI-induced cognitive impairment were not different between male and female mice. Here, CXCL12 is linked to Cognitive impairment.