HAS2 and neoplasm: Nobutaka Kobayashi and co-workers found that TAMs preferentially traffic to hyaluronan-enriched areas, and genetic disruption of the hyaluronan synthase 2 (Has2) gene in fibroblasts impairs TAM recruitment and reduces tumor angiogenesis and lymphangiogenesis, which indicates that CAF secretion of hyaluronan results in TAM pro-tumoral activities 120.