The AMPK stress-induced pathway is hijacked by GSCs for their adaptation to tumor-related stressors in the microenvironment through the Cyclic AMP-Responsive Element-Binding Protein 1 (CREB1) transcriptional program that controls both HIF-1 and GA Binding Protein Transcription Factor Subunit Alpha (GABPA) expression. The gene discussed is CREB1; the disease is neoplasm.