EGFR and breast carcinoma: Some of the commonly targeted receptors include the epidermal growth factor receptor (EGFR) family which are overexpressed in breast cancer and stimulate different downstream signaling pathways such as angiogenesis, proliferation, and migration of cancer cells 13; transferrin receptor for brain drug delivery 14; and integrin αvβ3, a cell adhesion receptor that is overexpressed in several types of cancer 15.