Given that the NLRP3 inflammasome plays a central role in chronic inflammatory diseases such as NASH and displays a circadian rhythmicity, it was hypothesized that NLRP3 inflammasome and steatohepatitis may be regulated by an oscillating lncRNA (i.e., rhythmically expressed). The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatohepatitis.